Chlorhexidine-loaded xanthan gum-based biopolymers for targeted, sustained release of antiseptic agent

Abstract

We engineered a chlorhexidine-loaded xanthan gum-based biopolymer for the targeted release ofantiseptic agent. To increase the viscosity and adherent properties of the xanthan gum scaffold,biocompatible materials were prepared and added to the scaffold. The chlorhexidine-loaded xanthangum was gelated prior to physicochemical characterization, and exhibited shear-thinning behavior. Rheological studies were performed to measure biopolymer viscosity using a Brookfield viscometor. Asxanthan gum concentration increased, biopolymer viscosity increased as well. Addition of variousbiocompatible materials resulted in higher or similar viscosities as compared to the chlorhexidine-loaded xanthan gum-based chlorhexidine biopolymer. In this study, we prepared biocompatible,antiseptic, xanthan gum-based biopolymers for the targeted delivery of chlorhexidine. Similarbiomaterials may have potential as effective local treatment modalities for temporary disinfectionpurpose in medical applications.