Chlorhexidine-loaded xanthan gum-based biopolymers for targeted, sustained release of antiseptic agent
- Authors
- Kim, Jieun; Hwang, Jangsun; Kang, Hochang; Choi, Jonghoon
- Issue Date
- Dec-2015
- Publisher
- 한국공업화학회
- Keywords
- Chlorhexidine; Xanthan gum biopolymer; Sustained delivery; Antiseptic reagent
- Citation
- Journal of Industrial and Engineering Chemistry, v.32, pp 44 - 48
- Pages
- 5
- Journal Title
- Journal of Industrial and Engineering Chemistry
- Volume
- 32
- Start Page
- 44
- End Page
- 48
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10097
- DOI
- 10.1016/j.jiec.2015.09.024
- ISSN
- 1226-086X
- Abstract
- We engineered a chlorhexidine-loaded xanthan gum-based biopolymer for the targeted release ofantiseptic agent. To increase the viscosity and adherent properties of the xanthan gum scaffold,biocompatible materials were prepared and added to the scaffold. The chlorhexidine-loaded xanthangum was gelated prior to physicochemical characterization, and exhibited shear-thinning behavior.
Rheological studies were performed to measure biopolymer viscosity using a Brookfield viscometor. Asxanthan gum concentration increased, biopolymer viscosity increased as well. Addition of variousbiocompatible materials resulted in higher or similar viscosities as compared to the chlorhexidine-loaded xanthan gum-based chlorhexidine biopolymer. In this study, we prepared biocompatible,antiseptic, xanthan gum-based biopolymers for the targeted delivery of chlorhexidine. Similarbiomaterials may have potential as effective local treatment modalities for temporary disinfectionpurpose in medical applications.
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