Risk of Hip Fractures in Men with Alpha-Blockers: A Nationwide Study Base on Claim Registryopen access
- Authors
- 서기현; 이영균; 하용찬
- Issue Date
- 2015
- Publisher
- 대한골대사학회
- Keywords
- Alpha-blocker; Hip fracture; Registries
- Citation
- 대한골대사학회지, v.22, no.1, pp 29 - 32
- Pages
- 4
- Journal Title
- 대한골대사학회지
- Volume
- 22
- Number
- 1
- Start Page
- 29
- End Page
- 32
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11173
- DOI
- 10.11005/jbm.2015.22.1.29
- ISSN
- 2287-6375
2287-7029
- Abstract
- Background: Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database. Methods: We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR). Results: Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker. Conclusions: Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
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