β-Caryophyllene attenuates dextran sulfate sodium-induced colitis in mice via modulation of gene expression associated mainly with colon inflammation
DC Field | Value | Language |
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dc.contributor.author | Cho, Jae Young | - |
dc.contributor.author | Kim, Hwa Yeon | - |
dc.contributor.author | Kim, Sung-Kyu | - |
dc.contributor.author | Park, Jung Han Yoon | - |
dc.contributor.author | Lee, Hong Jin | - |
dc.contributor.author | Chun, Hyang Sook | - |
dc.date.available | 2019-03-08T20:01:31Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2214-7500 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11284 | - |
dc.description.abstract | We examined the modulatory activity of β-caryophyllene (CA) and gene expression in colitic colon tissues in a dextran sulfate sodium (DSS)-induced colitis model. Experimental colitis was induced by exposing male BALB/c mice to 5% DSS in drinking water for 7 days. CA (30 or 300. mg/kg) was administered orally once a day together with DSS. CA administration attenuated the increases in the disease activity index, colon weight/length ratio, inflammation score, and myeloperoxidase activity in DSS-treated mice. Microarray analysis showed that CA administration regulated the expression in colon tissue of inflammation-related genes including those for cytokines and chemokines (Ccl2, Ccl7, Ccl11, Ifitm3, IL-1β, IL-28, Tnfrsf1b, Tnfrsf12a); acute-phase proteins (S100a8, Saa3, Hp); adhesion molecules (Cd14, Cd55, Cd68, Mmp3, Mmp10, Sema6b, Sema7a, Anax13); and signal regulatory proteins induced by DSS. CA significantly suppressed NF-κB activity, which mediates the expression of a different set of genes. These results suggest that CA attenuates DSS-induced colitis, possibly by modulating the expression of genes associated mainly with colon inflammation through inhibition of DSS-induced NF-κB activity. © 2015. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | β-Caryophyllene attenuates dextran sulfate sodium-induced colitis in mice via modulation of gene expression associated mainly with colon inflammation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.toxrep.2015.07.018 | - |
dc.identifier.bibliographicCitation | Toxicology Reports, v.2, pp 1039 - 1045 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-84938690019 | - |
dc.citation.endPage | 1045 | - |
dc.citation.startPage | 1039 | - |
dc.citation.title | Toxicology Reports | - |
dc.citation.volume | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | Dextran sulfate sodium | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | β-Caryophyllene (PubChem CID5281515) | - |
dc.description.journalRegisteredClass | scopus | - |
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