Fabrication of Compound K-loaded Polymeric Micelle System and its Characterization in vitro and Oral Absorption Enhancement in vivo
DC Field | Value | Language |
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dc.contributor.author | Hong, Sun-Mi | - |
dc.contributor.author | Jeon, Sang-ok | - |
dc.contributor.author | Seo, Jo-Eun | - |
dc.contributor.author | Chun, Kyeung-Hwa | - |
dc.contributor.author | Oh, Dong-Ho | - |
dc.contributor.author | Choi, Young Wook | - |
dc.contributor.author | Lee, Do Ik | - |
dc.contributor.author | Jeong, Seong Hoon | - |
dc.contributor.author | Kang, Jae Seon | - |
dc.contributor.author | Lee, Sangkil | - |
dc.date.available | 2019-03-08T20:56:20Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11589 | - |
dc.description.abstract | Compound K (CK) was formulated as polymeric micelles (PM) using Pluronic((R)) F-127 to enhance the oral absorption of CK, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin. The physicochemical properties of Ck-loaded PM were characterized and an in vitro transport study using the Caco-2 cell system as well as an in vivo pharmacokinetic study using SD rats was carried out. The hydrodynamic mean particle size of CK-loaded PM (CK-PM) was 254 +/- 23.45 nm after rehydration and the drug loading efficiency was ca. 99.9%. The FT-IR. spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy data supported the presence of a new solid phase in the PM. The P-app value of in vitro Caco-2 cell permeation of CK-PM and the oral absorption of CK was enhanced about 1.2-fold and 2.6-fold compared to CK suspension, respectively, showing that the present PM formulation enabled an enhancement of oral CK absorption. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Fabrication of Compound K-loaded Polymeric Micelle System and its Characterization in vitro and Oral Absorption Enhancement in vivo | - |
dc.type | Article | - |
dc.identifier.doi | 10.5012/bkcs.2014.35.11.3188 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.11, pp 3188 - 3194 | - |
dc.identifier.kciid | ART001920269 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000344583300008 | - |
dc.identifier.scopusid | 2-s2.0-84926661541 | - |
dc.citation.endPage | 3194 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3188 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 35 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Absorption enhancement | - |
dc.subject.keywordAuthor | Compound K | - |
dc.subject.keywordAuthor | Ginseng saponins | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
dc.subject.keywordAuthor | Polymeric micelle | - |
dc.subject.keywordPlus | GINSENG SAPONIN METABOLITE | - |
dc.subject.keywordPlus | INTESTINAL BACTERIAL METABOLITE | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ASSEMBLIES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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