Fabrication of Compound K-loaded Polymeric Micelle System and its Characterization in vitro and Oral Absorption Enhancement in vivo
- Authors
- Hong, Sun-Mi; Jeon, Sang-ok; Seo, Jo-Eun; Chun, Kyeung-Hwa; Oh, Dong-Ho; Choi, Young Wook; Lee, Do Ik; Jeong, Seong Hoon; Kang, Jae Seon; Lee, Sangkil
- Issue Date
- Nov-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Absorption enhancement; Compound K; Ginseng saponins; Pharmacokinetics; Polymeric micelle
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.11, pp 3188 - 3194
- Pages
- 7
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 35
- Number
- 11
- Start Page
- 3188
- End Page
- 3194
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11589
- DOI
- 10.5012/bkcs.2014.35.11.3188
- ISSN
- 1229-5949
1229-5949
- Abstract
- Compound K (CK) was formulated as polymeric micelles (PM) using Pluronic((R)) F-127 to enhance the oral absorption of CK, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin. The physicochemical properties of Ck-loaded PM were characterized and an in vitro transport study using the Caco-2 cell system as well as an in vivo pharmacokinetic study using SD rats was carried out. The hydrodynamic mean particle size of CK-loaded PM (CK-PM) was 254 +/- 23.45 nm after rehydration and the drug loading efficiency was ca. 99.9%. The FT-IR. spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy data supported the presence of a new solid phase in the PM. The P-app value of in vitro Caco-2 cell permeation of CK-PM and the oral absorption of CK was enhanced about 1.2-fold and 2.6-fold compared to CK suspension, respectively, showing that the present PM formulation enabled an enhancement of oral CK absorption.
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