The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells
DC Field | Value | Language |
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dc.contributor.author | An, Joo-Hee | - |
dc.contributor.author | Jang, Sang-Min | - |
dc.contributor.author | Kim, Jung-Woong | - |
dc.contributor.author | Kim, Chul-Hong | - |
dc.contributor.author | Song, Peter I. | - |
dc.contributor.author | Choi, Kyung-Hee | - |
dc.date.available | 2019-03-08T20:56:43Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.issn | 1873-3468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11607 | - |
dc.description.abstract | The expression of the cell cycle inhibitor p21 is increased in response to various stimuli and stress signals through p53-dependent and independent pathways. We demonstrate in this study that forkhead box A1/2 (FOXA1/2) is a crucial transcription factor in the activation of p21 transcription via direct binding to the p21 promoter in p53-null H1299 lung carcinoma cells. In addition, histone deacetylase inhibitor trichostatin A (TSA)-mediated upregulation of p21 expression was repressed by knockdown of FOXA1/2 in H1299 cells. Consequently, these results suggest that FOXA1/2 is required for p53-independent p21 expression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.febslet.2014.09.033 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.588, no.21, pp 4065 - 4070 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000344075400040 | - |
dc.identifier.scopusid | 2-s2.0-84908180899 | - |
dc.citation.endPage | 4070 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 4065 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 588 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Transcription factor FOXA1/2 | - |
dc.subject.keywordAuthor | p21 | - |
dc.subject.keywordAuthor | Trichostatin A | - |
dc.subject.keywordAuthor | Target gene | - |
dc.subject.keywordAuthor | p53-Independent pathway | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE INHIBITORS | - |
dc.subject.keywordPlus | HEPATOCYTE NUCLEAR FACTOR-3-BETA | - |
dc.subject.keywordPlus | WAF1/CIP1 GENE PROMOTER | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | SP1 SITES | - |
dc.subject.keywordPlus | P21(WAF1/CIP1) EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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