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The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells
- Authors
- An, Joo-Hee; Jang, Sang-Min; Kim, Jung-Woong; Kim, Chul-Hong; Song, Peter I.; Choi, Kyung-Hee
- Issue Date
- Nov-2014
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Transcription factor FOXA1/2; p21; Trichostatin A; Target gene; p53-Independent pathway
- Citation
- FEBS LETTERS, v.588, no.21, pp 4065 - 4070
- Pages
- 6
- Journal Title
- FEBS LETTERS
- Volume
- 588
- Number
- 21
- Start Page
- 4065
- End Page
- 4070
- ISSN
- 0014-5793
1873-3468
- Abstract
- The expression of the cell cycle inhibitor p21 is increased in response to various stimuli and stress signals through p53-dependent and independent pathways. We demonstrate in this study that forkhead box A1/2 (FOXA1/2) is a crucial transcription factor in the activation of p21 transcription via direct binding to the p21 promoter in p53-null H1299 lung carcinoma cells. In addition, histone deacetylase inhibitor trichostatin A (TSA)-mediated upregulation of p21 expression was repressed by knockdown of FOXA1/2 in H1299 cells. Consequently, these results suggest that FOXA1/2 is required for p53-independent p21 expression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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