Palonosetron and aprepitant for the prevention of postoperative nausea and vomiting in patients indicated for laparoscopic gynaecologic surgery: a double-blind randomised trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Hyoung Yong | - |
dc.contributor.author | Baek, Chong Wha | - |
dc.contributor.author | Choi, Geun Joo | - |
dc.contributor.author | Shin, Hwa Yong | - |
dc.contributor.author | Kang, Hyun | - |
dc.contributor.author | Jung, Yong Hun | - |
dc.contributor.author | Woo, Young Cheol | - |
dc.contributor.author | Kim, Jin Yun | - |
dc.contributor.author | Park, Seul Gi | - |
dc.date.available | 2019-03-08T21:37:20Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11927 | - |
dc.description.abstract | Background: Postoperative nausea and vomiting (PONV) is one of the most common postsurgical complications. Palonosetron, a 5-hydroxytryptamine receptor antagonist, is effective for PONV prevention. Herein, we compared palonosetron and aprepitant (a neurokinin-1 receptor antagonist) for PONV prevention in patients indicated for laparoscopic gynaecologic surgery. Methods: Ninety-three patients who were scheduled to undergo laparoscopic gynaecologic surgery under general anaesthesia were assigned to receive either a single intravenous injection of 0.075-mg palonosetron or 40-mg oral aprepitant in a double-blind randomised trial. The primary efficacy end points included complete response (visual analogue scale [VAS] nausea score <4 and no use of rescue therapy) 0-48 h after surgery. Nausea severity (0-10) and use of rescue therapy were monitored for 0-48 h. The secondary efficacy end points were the effect of aprepitant quantified using a 10-point VAS for pain, consumption of intravenous patient-controlled analgesia, and use of rescue analgesics. Results: Aprepitant was non-inferior to palonosetron in terms of complete response 0-48 hours after surgery (74% vs. 77%). At 0 and 2 h after administration, the nausea severity with 40-mg aprepitant was significantly lesser than that with 0.075-mg palonosetron (P < 0.05). At 6 and 24 h after administration, fentanyl consumption with 40-mg aprepitant was significantly lower than that with 0.075-mg palonosetron. Greater amounts of rescue analgesics were required in the aprepitant group. Conclusions: Palonosetron and aprepitant were both effective for PONV prevention in the patients indicated for laparoscopic gynaecologic surgery. The drugs can be used in combination for multimodal therapy because they bind to different receptors. More research is needed to evaluate the effects of aprepitant on pain management in humans. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Palonosetron and aprepitant for the prevention of postoperative nausea and vomiting in patients indicated for laparoscopic gynaecologic surgery: a double-blind randomised trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/1471-2253-14-68 | - |
dc.identifier.bibliographicCitation | BMC ANESTHESIOLOGY, v.14, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000340907500001 | - |
dc.identifier.scopusid | 2-s2.0-84906833815 | - |
dc.citation.number | 1 | - |
dc.citation.title | BMC ANESTHESIOLOGY | - |
dc.citation.volume | 14 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Palonosetron | - |
dc.subject.keywordAuthor | Aprepitant | - |
dc.subject.keywordAuthor | Laparoscopic | - |
dc.subject.keywordAuthor | Gynaecologic | - |
dc.subject.keywordAuthor | PONV | - |
dc.subject.keywordPlus | ONDANSETRON | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.