Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression
DC Field | Value | Language |
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dc.contributor.author | Kim, Yesl | - |
dc.contributor.author | Kim, Jung Hyun | - |
dc.contributor.author | Lee, Seung Min | - |
dc.date.available | 2019-03-08T21:38:58Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11998 | - |
dc.description.abstract | Rubus coreanus Miquel (RCM) is used to promote prostate health and has been shown to have antioxidant and anti-carcinogenic activities. However, the effects and mechanisms of RCM on prostate cancer metastasis remain unclear. PC-3 and DU 145 cells were treated with ethanol or water extract of unripe or ripe RCM and examined for cell invasion, migration, and matrix metalloproteinases (MMPs) activity and expression. Phosphoinositide 3-kinase (PI3K) and Akt activities were examined. Unripe RCM extracts exerted significant inhibitory effects on cell migration, invasion, and MMPs activities. A significant reduction in MMPs activities by unripe RCM ethanol extract treatment (UE) was associated with reduction of MMPs expression and induction of tissue inhibitors of metalloproteinases (TIMPs) expression. Furthermore, PI3K/Akt activity was diminished by UE treatment. In this study, we demonstrated that UE decreased metastatic potential of prostate cancer cells by reducing MMPs expression through the suppression of PI3K/Akt phosphorylation, thereby decreasing MMP activity and enhancing TIMPs expression. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/09168451.2014.921550 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.78, no.8, pp 1402 - 1411 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000340722500018 | - |
dc.identifier.scopusid | 2-s2.0-84928052066 | - |
dc.citation.endPage | 1411 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1402 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 78 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | Rubus coreanus Miquel | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | matrix metalloproteinase (MMP) | - |
dc.subject.keywordAuthor | tissue inhibitors of metalloproteinase(TIMP) | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | CARCINOMA-CELLS | - |
dc.subject.keywordPlus | INDUCED ANGIOGENESIS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | MMP-9 | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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