Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression
- Authors
- Kim, Yesl; Kim, Jung Hyun; Lee, Seung Min
- Issue Date
- Aug-2014
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Rubus coreanus Miquel; prostate cancer; metastasis; matrix metalloproteinase (MMP); tissue inhibitors of metalloproteinase(TIMP)
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.78, no.8, pp 1402 - 1411
- Pages
- 10
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 78
- Number
- 8
- Start Page
- 1402
- End Page
- 1411
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11998
- DOI
- 10.1080/09168451.2014.921550
- ISSN
- 0916-8451
1347-6947
- Abstract
- Rubus coreanus Miquel (RCM) is used to promote prostate health and has been shown to have antioxidant and anti-carcinogenic activities. However, the effects and mechanisms of RCM on prostate cancer metastasis remain unclear. PC-3 and DU 145 cells were treated with ethanol or water extract of unripe or ripe RCM and examined for cell invasion, migration, and matrix metalloproteinases (MMPs) activity and expression. Phosphoinositide 3-kinase (PI3K) and Akt activities were examined. Unripe RCM extracts exerted significant inhibitory effects on cell migration, invasion, and MMPs activities. A significant reduction in MMPs activities by unripe RCM ethanol extract treatment (UE) was associated with reduction of MMPs expression and induction of tissue inhibitors of metalloproteinases (TIMPs) expression. Furthermore, PI3K/Akt activity was diminished by UE treatment. In this study, we demonstrated that UE decreased metastatic potential of prostate cancer cells by reducing MMPs expression through the suppression of PI3K/Akt phosphorylation, thereby decreasing MMP activity and enhancing TIMPs expression.
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Collections - College of Education > Department of Physical Education > 1. Journal Articles
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