Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Dae | - |
dc.contributor.author | Yim, Dong-Hyuk | - |
dc.contributor.author | Eom, Sang-Yong | - |
dc.contributor.author | Moon, Sun-In | - |
dc.contributor.author | Park, Choong-Hee | - |
dc.contributor.author | Kim, Guen-Bae | - |
dc.contributor.author | Yu, Seung-Do | - |
dc.contributor.author | Choi, Byung-Sun | - |
dc.contributor.author | Park, Jung-Duck | - |
dc.contributor.author | Kim, Heon | - |
dc.date.available | 2019-03-08T21:41:30Z | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1382-6689 | - |
dc.identifier.issn | 1872-7077 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12109 | - |
dc.description.abstract | This study aimed to estimate the risks for renal tubular damage and osteoporosis in individuals with long-term environmental Cd exposure. This cross-sectional study comprised 1086 residents living in the vicinity of a copper refinery plant. As the urinary Cd levels increased, the proportion of female subjects with beta(2)-MG >= 300 mu g/g creatinine also increased significantly, but this was not observed in the male subjects. The prevalence of osteoporosis was significantly higher in men with urinary Cd >5 mu g/g creatinine than in those with urinary Cd <= 5 mu g/g creatinine. This difference was not observed in the corresponding female groups. The association between increased urinary excretion of beta(2)-MG and decreased BMD was statistically significant only in the female subjects. We suggest that an increased Cd body burden directly decreases the BMD in male subjects; however, in female subjects, it first induces renal microtubular damage, which can lead to osteoporosis. (C) 2014 Published by Elsevier B.V. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.etap.2014.06.002 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.38, no.1, pp 272 - 278 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000341468900030 | - |
dc.identifier.scopusid | 2-s2.0-84903464620 | - |
dc.citation.endPage | 278 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 272 | - |
dc.citation.title | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Cadmium | - |
dc.subject.keywordAuthor | beta(2)-Microglobulin | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | Sex difference | - |
dc.subject.keywordAuthor | Tubular damage | - |
dc.subject.keywordPlus | ENVIRONMENTAL EXPOSURE | - |
dc.subject.keywordPlus | URINARY CADMIUM | - |
dc.subject.keywordPlus | BONE-DENSITY | - |
dc.subject.keywordPlus | GENERAL-POPULATION | - |
dc.subject.keywordPlus | JAPANESE WOMEN | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | METALLOTHIONEIN | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | BLOOD | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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