Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex
- Authors
- Kim, Yong-Dae; Yim, Dong-Hyuk; Eom, Sang-Yong; Moon, Sun-In; Park, Choong-Hee; Kim, Guen-Bae; Yu, Seung-Do; Choi, Byung-Sun; Park, Jung-Duck; Kim, Heon
- Issue Date
- Jul-2014
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Cadmium; beta(2)-Microglobulin; Osteoporosis; Sex difference; Tubular damage
- Citation
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.38, no.1, pp 272 - 278
- Pages
- 7
- Journal Title
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Volume
- 38
- Number
- 1
- Start Page
- 272
- End Page
- 278
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12109
- DOI
- 10.1016/j.etap.2014.06.002
- ISSN
- 1382-6689
1872-7077
- Abstract
- This study aimed to estimate the risks for renal tubular damage and osteoporosis in individuals with long-term environmental Cd exposure. This cross-sectional study comprised 1086 residents living in the vicinity of a copper refinery plant. As the urinary Cd levels increased, the proportion of female subjects with beta(2)-MG >= 300 mu g/g creatinine also increased significantly, but this was not observed in the male subjects. The prevalence of osteoporosis was significantly higher in men with urinary Cd >5 mu g/g creatinine than in those with urinary Cd <= 5 mu g/g creatinine. This difference was not observed in the corresponding female groups. The association between increased urinary excretion of beta(2)-MG and decreased BMD was statistically significant only in the female subjects. We suggest that an increased Cd body burden directly decreases the BMD in male subjects; however, in female subjects, it first induces renal microtubular damage, which can lead to osteoporosis. (C) 2014 Published by Elsevier B.V.
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