Surface Modification of Silk Fibroin Nanofibrous Mat with Dextran for Wound Dressing
- Authors
- Kim, Moo Kon; Kwak, Hyo Won; Kim, Hyung Hwan; Kwon, Tae Rin; Kim, So Young; Kim, Beom Joon; Park, Young Hwan; Lee, Ki Hoon
- Issue Date
- Jun-2014
- Publisher
- KOREAN FIBER SOC
- Keywords
- Silk fibroin; Dextran; Wound healing; Wound dressing; Surface modification
- Citation
- FIBERS AND POLYMERS, v.15, no.6, pp 1137 - 1145
- Pages
- 9
- Journal Title
- FIBERS AND POLYMERS
- Volume
- 15
- Number
- 6
- Start Page
- 1137
- End Page
- 1145
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12196
- DOI
- 10.1007/s12221-014-1137-2
- ISSN
- 1229-9197
1875-0052
- Abstract
- In this study, we examined the effects of a dextran-modified silk fibroin nanofibrous mat (D-SFNM) on wound healing. To increase the hydrophilicity of silk fibroin (SF), the SF nanofibrous mat (SFNM) was modified with oxidized dextran. The D-SFNM absorbed water faster than the SFNM, and the swelling ratio was increased by approximately 80 % compared with the SFNM. An in vitro cell (NIH3T3) test revealed that fewer cells attached to the D-SFNM than the SFNM, but the proliferation of cells was not significantly affected by the presence of dextran. An in vivo wound healing test with mice indicated that the D-SFNM resulted in a good wound recovery effect similar to a commercial wound dressing material. The increased hydrophilicity of the D-SFNM might balance the moist environment at the wound site, which improves the wound healing compared with the SFNM.
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