Picrasma quassioides inhibits LPS- and IFN-gamma-stimulated nitric oxide production and inflammatory response in RAW264.7 macrophage cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Yi Seop | - |
dc.contributor.author | Lee, Yonghee | - |
dc.contributor.author | Kwon, Tae-Rin | - |
dc.contributor.author | Kim, Young Heui | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.date.available | 2019-03-08T21:57:05Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1226-8372 | - |
dc.identifier.issn | 1976-3816 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12204 | - |
dc.description.abstract | The present study was designed to investigate the anti-inflammatory effects of Picrasma quassioides (P. quassioides) in lipopolysaccharide (LPS)- and interferon (IFN)-gamma-stimulated RAW 264.7 cells. P. quassioides has been used as a traditional medicine for the treatment of gastro-enteritis, eczema, and snakebite. P. quassioides significantly decreased LPS- and IFN-gamma-stimulated nitric oxide (NO) production in a concentration-dependent manner. Real-time PCR or Western blotting confirmed that the expression of the extra-cellular signal-regulated kinase (ERK), p42 and, p38 mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) mediated MAPK signaling pathways in LPS- and IFN-gamma-stimulated RAW264.7 cells. Mechanistic studies revealed the activities of nuclear factor kappa B (NF-kappa B). As P. quassioides regulated the gene expression of iNOS and COX-2 in RAW264.7 cells, it might be a promising agent for the prevention and/or treatment of various inflammatory diseases. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING | - |
dc.title | Picrasma quassioides inhibits LPS- and IFN-gamma-stimulated nitric oxide production and inflammatory response in RAW264.7 macrophage cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12257-014-0131-4 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.19, no.3, pp 404 - 410 | - |
dc.identifier.kciid | ART001892797 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000339731700004 | - |
dc.identifier.scopusid | 2-s2.0-84905435493 | - |
dc.citation.endPage | 410 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 404 | - |
dc.citation.title | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ERK1/2 | - |
dc.subject.keywordPlus | STEMS | - |
dc.subject.keywordPlus | INACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.