Picrasma quassioides inhibits LPS- and IFN-gamma-stimulated nitric oxide production and inflammatory response in RAW264.7 macrophage cells
- Authors
- Song, Yi Seop; Lee, Yonghee; Kwon, Tae-Rin; Kim, Young Heui; Kim, Beom Joon
- Issue Date
- Jun-2014
- Publisher
- KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
- Keywords
- LPS; nitric oxide; iNOS; MAPK
- Citation
- BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.19, no.3, pp 404 - 410
- Pages
- 7
- Journal Title
- BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
- Volume
- 19
- Number
- 3
- Start Page
- 404
- End Page
- 410
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12204
- DOI
- 10.1007/s12257-014-0131-4
- ISSN
- 1226-8372
1976-3816
- Abstract
- The present study was designed to investigate the anti-inflammatory effects of Picrasma quassioides (P. quassioides) in lipopolysaccharide (LPS)- and interferon (IFN)-gamma-stimulated RAW 264.7 cells. P. quassioides has been used as a traditional medicine for the treatment of gastro-enteritis, eczema, and snakebite. P. quassioides significantly decreased LPS- and IFN-gamma-stimulated nitric oxide (NO) production in a concentration-dependent manner. Real-time PCR or Western blotting confirmed that the expression of the extra-cellular signal-regulated kinase (ERK), p42 and, p38 mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) mediated MAPK signaling pathways in LPS- and IFN-gamma-stimulated RAW264.7 cells. Mechanistic studies revealed the activities of nuclear factor kappa B (NF-kappa B). As P. quassioides regulated the gene expression of iNOS and COX-2 in RAW264.7 cells, it might be a promising agent for the prevention and/or treatment of various inflammatory diseases.
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