The Metabotropic Glutamate Receptor Subtype 7 rs3792452 Polymorphism Is Associated with the Response to Methylphenidate in Children with Attention-Deficit/Hyperactivity Disorder
- Authors
- Park, Subin; Kim, Bung-Nyun; Cho, Soo-Churl; Kim, Jae-Won; Kim, Johanna Inhyang; Shin, Min-Sup; Yoo, Hee-Jeong; Han, Doug Hyun; Cheong, Jae Hoon
- Issue Date
- May-2014
- Publisher
- MARY ANN LIEBERT, INC
- Citation
- JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, v.24, no.4, pp 223 - 227
- Pages
- 5
- Journal Title
- JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
- Volume
- 24
- Number
- 4
- Start Page
- 223
- End Page
- 227
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12269
- DOI
- 10.1089/cap.2013.0079
- ISSN
- 1044-5463
1557-8992
- Abstract
- Objective: The purpose of this study was to investigate the association between the metabotropic glutamate receptor subtype 7 (mGluR7) gene (GRM7) polymorphism and treatment response to methylphenidate in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: We enrolled 175 medication-naive children with ADHD in an open-label 8 week trial of methylphenidate. The participants were genotyped and evaluated using the Clinical Global Impressions (CGI) Scale and the parent version of the ADHD Rating Scale-IV (ADHD-RS) before and after treatment. Results: After the 8 week course of methylphenidate, children with the GRM7 rs37952452 polymorphism G/A genotype had a more pronounced response rate to the treatment than did children with the G/G genotype according to the ADHD-RS scores (72.2% vs. 55.4%, respectively; p=0.011) and the more stringent standard of combined ADHD-RS and CGI-Improvement (CGI-I) scores (50.0% vs. 35.3%, respectively; p=0.044). Conclusions: The present study suggests that the GRM7 rs37952452 polymorphism may play a role in the treatment response to methylphenidate in children with ADHD. Further studies to evaluate the association between glutamate genes and treatment response to methylphenidate in children with ADHD, including a replication of our findings using a control or comparative group in a larger sample, are warranted.
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