Detailed Information

Cited 7 time in webofscience Cited 6 time in scopus
Metadata Downloads

The impact of RNA structure on coding sequence evolution in both bacteria and eukaryotes

Authors
Gu, WanjunLi, MushengXu, YumingWang, TingKo, Jae-HongZhou, Tong
Issue Date
23-Apr-2014
Publisher
BIOMED CENTRAL LTD
Keywords
mRNA structure; Purifying selection; Synonymous mutation; Translation initiation; Codon usage bias; Gene expression
Citation
BMC EVOLUTIONARY BIOLOGY, v.14, no.1
Journal Title
BMC EVOLUTIONARY BIOLOGY
Volume
14
Number
1
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12313
DOI
10.1186/1471-2148-14-87
ISSN
1471-2148
Abstract
Background: Many studies have found functional RNA secondary structures are selectively conserved among species. But, the effect of RNA structure selection on coding sequence evolution remains unknown. To address this problem, we systematically investigated the relationship between nucleotide conservation level and its structural sensitivity in four model organisms, Escherichia coli, yeast, fly, and mouse. Results: We define structurally sensitive sites as those with putative local structure-disruptive mutations. Using both the Mantel-Haenszel procedure and association test, we found structurally sensitive nucleotide sites evolved more slowly than non-sensitive sites in all four organisms. Furthermore, we observed that this association is more obvious in highly expressed genes and region near the start codon. Conclusion: We conclude that structurally sensitive sites in mRNA sequences normally have less nucleotide divergence in all species we analyzed. This study extends our understanding of the impact of RNA structure on coding sequence evolution, and is helpful to the development of a codon model with RNA structure information.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > College of Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Ko, Jae-Hong photo

Ko, Jae-Hong
의과대학 (의학부(기초))
Read more

Altmetrics

Total Views & Downloads

BROWSE