Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics
DC Field | Value | Language |
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dc.contributor.author | Park, Tae-Joon | - |
dc.contributor.author | Kim, Jeong-Hyun | - |
dc.contributor.author | Pasaje, Charisse F. | - |
dc.contributor.author | Park, Byung-Lae | - |
dc.contributor.author | Bae, Joon Seol | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Kim, Yong-Hoon | - |
dc.contributor.author | Kim, Mi-Kyeong | - |
dc.contributor.author | Choi, Inseon S. | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Shin, Hye-Rim | - |
dc.contributor.author | Park, Jong-Sook | - |
dc.contributor.author | Koh, InSong | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.date.available | 2019-03-08T22:02:47Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12444 | - |
dc.description.abstract | Purpose: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 613 (ATF6B) is known to regulate ATFa-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation. Methods: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls. Results: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD. Conclusions: Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.title | Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics | - |
dc.type | Article | - |
dc.identifier.doi | 10.4168/aair.2014.6.2.142 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.6, no.2, pp 142 - 148 | - |
dc.identifier.kciid | ART001850734 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000333066600008 | - |
dc.identifier.scopusid | 2-s2.0-84894472552 | - |
dc.citation.endPage | 148 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 142 | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 6 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | ATF6B | - |
dc.subject.keywordAuthor | aspirin exacerbated respiratory disease (AERD) | - |
dc.subject.keywordAuthor | single nucleotide polymorphism (SNP) | - |
dc.subject.keywordAuthor | haplotype | - |
dc.subject.keywordPlus | EXACERBATED RESPIRATORY-DISEASE | - |
dc.subject.keywordPlus | RETICULUM STRESS-RESPONSE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INTOLERANCE | - |
dc.subject.keywordPlus | ATF6-ALPHA | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ATF6-BETA | - |
dc.subject.keywordPlus | CA2+ | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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