Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics
- Authors
- Park, Tae-Joon; Kim, Jeong-Hyun; Pasaje, Charisse F.; Park, Byung-Lae; Bae, Joon Seol; Uh, Soo-Taek; Kim, Yong-Hoon; Kim, Mi-Kyeong; Choi, Inseon S.; Choi, Byoung Whui; Shin, Hye-Rim; Park, Jong-Sook; Koh, InSong; Park, Choon-Sik; Shin, Hyoung Doo
- Issue Date
- Mar-2014
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- ATF6B; aspirin exacerbated respiratory disease (AERD); single nucleotide polymorphism (SNP); haplotype
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.6, no.2, pp 142 - 148
- Pages
- 7
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 6
- Number
- 2
- Start Page
- 142
- End Page
- 148
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12444
- DOI
- 10.4168/aair.2014.6.2.142
- ISSN
- 2092-7355
2092-7363
- Abstract
- Purpose: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 613 (ATF6B) is known to regulate ATFa-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation. Methods: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls. Results: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD. Conclusions: Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics.
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