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Cited 16 time in webofscience Cited 23 time in scopus
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A Vanillin Derivative Causes Mitochondrial Dysfunction and Triggers Oxidative Stress in Cryptococcus neoformans

Authors
Kim, Jin HyoLee, Han-OkCho, Yong-JoonKim, JeongmiChun, JongsikChoi, JaehyukLee, YounghoonJung, Won Hee
Issue Date
Feb-2014
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.9, no.2
Journal Title
PLOS ONE
Volume
9
Number
2
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12476
DOI
10.1371/journal.pone.0089122
ISSN
1932-6203
Abstract
Vanillin is a well-known food and cosmetic additive and has antioxidant and antimutagenic properties. It has also been suggested to have antifungal activity against major human pathogenic fungi, although it is not very effective. In this study, the antifungal activities of vanillin and 33 vanillin derivatives against the human fungal pathogen Cryptococcus neoformans, the main pathogen of cryptococcal meningitis in immunocompromised patients, were investigated. We found a structural correlation between the vanillin derivatives and antifungal activity, showing that the hydroxyl or alkoxy group is more advantageous than the halogenated or nitrated group in benzaldehyde. Among the vanillin derivatives with a hydroxyl or alkoxy group, o-vanillin and o-ethyl vanillin showed the highest antifungal activity against C. neoformans. o-Vanillin was further studied to understand the mechanism of antifungal action. We compared the transcriptome of C. neoformans cells untreated or treated with o-vanillin by using RNA sequencing and found that the compound caused mitochondrial dysfunction and triggered oxidative stress. These antifungal mechanisms of o-vanillin were experimentally confirmed by the significantly reduced growth of the mutants lacking the genes involved in mitochondrial functions and oxidative stress response.
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Jung, Won Hee
생명공학대학 (시스템생명공학과)
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