Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodesopen access
- Authors
- Ha, Dae Chul; Lee, Ha Young; Son, Yeo Won; Yuk, Soon Hong; Choi, Youn Woong; Kwak, Byung Kook; Shin, Byung Cheol; Cho, Cheong-Weon; Cho, Sun Hang
- Issue Date
- Jan-2014
- Publisher
- SPRINGER
- Keywords
- Magnetic resonance imaging; Lymph node; Ultrasuperparamagnetic iron oxide; Nanoparticles
- Citation
- NANOSCALE RESEARCH LETTERS, v.9, no.1
- Journal Title
- NANOSCALE RESEARCH LETTERS
- Volume
- 9
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12586
- DOI
- 10.1186/1556-276X-9-38
- ISSN
- 1556-276X
1556-276X
- Abstract
- The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)-C-16-iron oxide (PHEA-C-16-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C-16-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C-16-iron oxide nanoparticles was about 5 to 7 nm, and the overall size of the nanoparticles was around 20, 60, and 150 nm in aqueous solution. The size of the nanoparticles was controlled by the amount of C-16. The 3.0-T MRI signal intensity of a rabbit lymph node was effectively reduced after intravenous administration of PHEA-C-16-iron oxide with the size of 20 nm. The in vitro and in vivo toxicity tests revealed the high biocompatibility of PHEA-C-16-iron oxide nanoparticles. Therefore, PHEA-C-16-iron oxide nanoparticles with 20-nm size can be potentially useful as T2-weighted MR imaging contrast agents for the detection of lymph nodes.
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