Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release
- Authors
- Park, SoHyun; Kwag, Dong Sup; Lee, Ung Yeol; Lee, Dong Jin; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong
- Issue Date
- Jan-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- porous microparticles; poly(lactide-co-glycolide); drug release kinetics; tiotropium; chronic obstructive pulmonary disease
- Citation
- POLYMERS FOR ADVANCED TECHNOLOGIES, v.25, no.1, pp 16 - 20
- Pages
- 5
- Journal Title
- POLYMERS FOR ADVANCED TECHNOLOGIES
- Volume
- 25
- Number
- 1
- Start Page
- 16
- End Page
- 20
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12609
- DOI
- 10.1002/pat.3198
- ISSN
- 1042-7147
1099-1581
- Abstract
- In this study, porous poly(lactide-co-glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water-in-oil-in-water (W-1/O/W-2) multi-emulsion method using PLGA polymer and ammonium bicarbonate (as a porogen). Herein, soluble starch was incorporated in porous PLGA microparticles for long-term tiotropium release. In vitro drug release studies determined that the rapid release of tiotropium from porous PLGA microparticles was reduced because of the high viscosity of the incorporated starch. Tiotropium release from porous PLGA microparticles continued up to 3days. Furthermore, the inhaled microparticles showed longer drug residence in in vivo lung epithelium. Copyright (c) 2013 John Wiley & Sons, Ltd.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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