Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice
- Authors
- Phuong-Tram Nguyen; Shin, Eun-Joo; Dang, Duy-Khanh; Tran, Hai-Quyen; Jang, Choon-Gon; Jeong, Ji Hoon; Lee, Yu Jeung; Lee, Hyo Jong; Lee, Yong Sup; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung-Chun
- Issue Date
- Feb-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- 3-Fluoromethamphetamine; Dopaminergic deficits; Striatum; Dopamine receptors; Oxidative stress; Apoptosis
- Citation
- NEUROCHEMISTRY INTERNATIONAL, v.113, pp 69 - 84
- Pages
- 16
- Journal Title
- NEUROCHEMISTRY INTERNATIONAL
- Volume
- 113
- Start Page
- 69
- End Page
- 84
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1280
- DOI
- 10.1016/j.neuint.2017.11.017
- ISSN
- 0197-0186
1872-9754
- Abstract
- 3-Fluoromethamphetamine (3-FMA) is an illegal designer drug of methamphetamine (MA) derivative. Up to date, little is known about the neurotoxic potential of 3-FMA. In the present study, we investigated the role of dopamine receptors in neurotoxicity induced by 3-FMA in comparison with MA (35 mg/kg, i.p.) as a control drug. Here we found that 3-FMA (40, 60 or 80 mg/kg, i.p.) produced mortality in a dose dependent manner in mice. Treatment with 3-FMA (40 mg/kg, i.p.) resulted in significant hyperthermia, oxidative stress and microgliosis (microglial differentiation into M1 phenotype) followed by proapoptotic changes and the induction of terminal deoxynucleotidyl transferase dUDP nick end labeling (TUNEL)-positive cells. Moreover, 3-FMA significantly produced dopaminergic impairments [i.e., increase in dopamine (DA) turnover rate and decreases in DA level, and in the expression of tyrosine hydroxylase (TH), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT-2)] with behavioral impairments. These dopaminergic neurotoxic effects of 3-FMA were comparable to those of MA. SCH23390, a dopamine D1 receptor antagonist, but not sulpiride, a dopamine D2 receptor antagonist significantly attenuated 3-FMA-induced neurotoxicity. Although both SCH23390 and sulpiride attenuated MA-induced dopaminergic neurotoxicity, sulpiride is more effective than SCH23390 on the dopaminergic neurotoxicity. Interestingly, SCH23390 treatment positively modulated 3-FMA-induced microglial activation (i.e., SCH23390 inhibited M1 phenotype from 3-FMA insult, but activated M2 phenotype). Therefore, our results suggest that the activation of dopamine D1 receptor is critical to 3-FMA-induced neurotoxicity, while both dopamine D1 and D2 receptors (dopamine D2 receptor > dopamine D1 receptor) mediate MA-induced dopaminergic neurotoxicity. (C) 2017 Elsevier Ltd. All rights reserved.
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