Callicarpa rubella for. angustata C. P’ei shows anti-inflammatory effects by blocking p38 activation in murine macrophages
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조영창 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 조사연 | - |
dc.date.available | 2019-03-08T23:36:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2288-6982 | - |
dc.identifier.issn | 2288-7105 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/13105 | - |
dc.description.abstract | Many attempts have been made to develop anti-inflammatory drugs by using natural products because natural productshave been traditionally used to cure severe inflammatory diseases. In this study, we investigated the anti-inflammatoryeffects and the molecular mechanisms underlying these effects in murine macrophages by using an ethanol extract ofCallicarpa rubella for. angustata C. P`ei (ECR). We found that ECR treatment significantly inhibited lipopolysaccharide(LPS)-stimulated nitric oxide (NO) production in macrophages and downregulated mRNA and protein expression levelsof inducible nitric oxide synthase (iNOS). However, ECR did not modulate cyclooxygenase-2 (COX-2) expression at bothmRNA and protein levels. Among the inflammatory cytokines, interleukin (IL)-1β production was reduced by ECR treatmentwhereas the level of IL-6 and tumor necrosis factor (TNF)-α was independent of ECR treatment. Western blot analysisrevealed that ECR notably reduced the phosphorylation of p38 but had no effect on the activation of nuclear factor kappaB (NF-κB) and other mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK) andc-Jun N-terminal kinase (JNK). These results imply that ECR exerts anti-inflammatory effects via selective inhibition of theproduction of inflammatory mediators including iNOS and IL-1β by inactivating p38. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국구조생물학회 | - |
dc.title | Callicarpa rubella for. angustata C. P’ei shows anti-inflammatory effects by blocking p38 activation in murine macrophages | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Biodesign, v.2, no.3, pp 108 - 115 | - |
dc.identifier.kciid | ART002262410 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 115 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 108 | - |
dc.citation.title | Biodesign | - |
dc.citation.volume | 2 | - |
dc.publisher.location | 대한민국 | - |
dc.description.journalRegisteredClass | domestic | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.