Callicarpa rubella for. angustata C. P’ei shows anti-inflammatory effects by blocking p38 activation in murine macrophages
- Authors
- 조영창; 천재희; 조사연
- Issue Date
- 2014
- Publisher
- 한국구조생물학회
- Citation
- Biodesign, v.2, no.3, pp 108 - 115
- Pages
- 8
- Journal Title
- Biodesign
- Volume
- 2
- Number
- 3
- Start Page
- 108
- End Page
- 115
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/13105
- ISSN
- 2288-6982
2288-7105
- Abstract
- Many attempts have been made to develop anti-inflammatory drugs by using natural products because natural productshave been traditionally used to cure severe inflammatory diseases. In this study, we investigated the anti-inflammatoryeffects and the molecular mechanisms underlying these effects in murine macrophages by using an ethanol extract ofCallicarpa rubella for. angustata C. P`ei (ECR). We found that ECR treatment significantly inhibited lipopolysaccharide(LPS)-stimulated nitric oxide (NO) production in macrophages and downregulated mRNA and protein expression levelsof inducible nitric oxide synthase (iNOS). However, ECR did not modulate cyclooxygenase-2 (COX-2) expression at bothmRNA and protein levels. Among the inflammatory cytokines, interleukin (IL)-1β production was reduced by ECR treatmentwhereas the level of IL-6 and tumor necrosis factor (TNF)-α was independent of ECR treatment. Western blot analysisrevealed that ECR notably reduced the phosphorylation of p38 but had no effect on the activation of nuclear factor kappaB (NF-κB) and other mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK) andc-Jun N-terminal kinase (JNK). These results imply that ECR exerts anti-inflammatory effects via selective inhibition of theproduction of inflammatory mediators including iNOS and IL-1β by inactivating p38.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/13105)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.