Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients
DC Field | Value | Language |
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dc.contributor.author | Lee, Seoung-Ae | - |
dc.contributor.author | Kim, Ki-Jeong | - |
dc.contributor.author | Kim, Dong-Won | - |
dc.contributor.author | Kim, Bum-Joon | - |
dc.date.available | 2019-03-09T00:58:00Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0095-1137 | - |
dc.identifier.issn | 1098-660X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14060 | - |
dc.description.abstract | The issue of hepatitis B virus (HBV) mutations possibly leading to a gender disparity in the progression of liver diseases has not been explored. We aimed to elucidate the relationships of the novel pre-S1 mutations, W4P/R, with the progression of liver diseases and male predominance in a South Korean chronic cohort by use of a molecular epidemiologic study. We developed a fluorescence resonance energy transfer (FRET)-based real-time PCR (RT-PCR) assay for the detection of the W4P/R mutations and applied it to 292 chronic HBV patients. The pre-S1 mutations from 247 (84.6%) of a total of 292 patients were detected by this assay. W4P/R mutants were found to be significantly related to severe liver diseases (hepatocellular carcinoma [HCC] and liver cirrhosis, 12.4% [19/153] of patients, versus chronic hepatitis and asymptomatic carriage, 1.1% [1/94] of patients) (P<0.001). All of the W4P/R mutants were found in males only. The novel HBV pre-S1 mutations, W4P/R, may be associated with disease severity in male patients chronically infected with HBV genotype C. The W4P/R mutations may provide in part an explanation for the relatively high ratio of male to female incidence in HCC generation in South Korean chronic HBV patients. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.title | Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1128/JCM.01505-13 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MICROBIOLOGY, v.51, no.12, pp 3928 - 3936 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000327147100004 | - |
dc.identifier.scopusid | 2-s2.0-84889835661 | - |
dc.citation.endPage | 3936 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3928 | - |
dc.citation.title | JOURNAL OF CLINICAL MICROBIOLOGY | - |
dc.citation.volume | 51 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | GENOTYPE-C | - |
dc.subject.keywordPlus | GENDER DISPARITY | - |
dc.subject.keywordPlus | SURFACE-ANTIGEN | - |
dc.subject.keywordPlus | KOREAN PATIENTS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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