Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients
- Authors
- Lee, Seoung-Ae; Kim, Ki-Jeong; Kim, Dong-Won; Kim, Bum-Joon
- Issue Date
- Dec-2013
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- JOURNAL OF CLINICAL MICROBIOLOGY, v.51, no.12, pp 3928 - 3936
- Pages
- 9
- Journal Title
- JOURNAL OF CLINICAL MICROBIOLOGY
- Volume
- 51
- Number
- 12
- Start Page
- 3928
- End Page
- 3936
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14060
- DOI
- 10.1128/JCM.01505-13
- ISSN
- 0095-1137
1098-660X
- Abstract
- The issue of hepatitis B virus (HBV) mutations possibly leading to a gender disparity in the progression of liver diseases has not been explored. We aimed to elucidate the relationships of the novel pre-S1 mutations, W4P/R, with the progression of liver diseases and male predominance in a South Korean chronic cohort by use of a molecular epidemiologic study. We developed a fluorescence resonance energy transfer (FRET)-based real-time PCR (RT-PCR) assay for the detection of the W4P/R mutations and applied it to 292 chronic HBV patients. The pre-S1 mutations from 247 (84.6%) of a total of 292 patients were detected by this assay. W4P/R mutants were found to be significantly related to severe liver diseases (hepatocellular carcinoma [HCC] and liver cirrhosis, 12.4% [19/153] of patients, versus chronic hepatitis and asymptomatic carriage, 1.1% [1/94] of patients) (P<0.001). All of the W4P/R mutants were found in males only. The novel HBV pre-S1 mutations, W4P/R, may be associated with disease severity in male patients chronically infected with HBV genotype C. The W4P/R mutations may provide in part an explanation for the relatively high ratio of male to female incidence in HCC generation in South Korean chronic HBV patients.
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