Aminopropyl carbazole analogues as potent enhancers of neurogenesis
- Authors
- Yoon, Hye Jin; Kong, Sun-Young; Park, Min-Hye; Cho, Yongsung; Kim, Sung-Eun; Shin, Jae-Yeon; Jung, Sunghye; Lee, Jiyoun; Farhanullah; Kim, Hyun-Jung; Lee, Jeewoo
- Issue Date
- Nov-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Neurogenesis; Neuroprotective agents; Neurodegenerative diseases; Aminopropyl carbazole; Neural stem cells
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY, v.21, no.22, pp 7165 - 7174
- Pages
- 10
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY
- Volume
- 21
- Number
- 22
- Start Page
- 7165
- End Page
- 7174
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14131
- DOI
- 10.1016/j.bmc.2013.08.066
- ISSN
- 0968-0896
1464-3391
- Abstract
- Neural stem cells are multipotent and self-renewing cells that can differentiate into new neurons and hold great promise for treating various neurological disorders including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Small molecules that can trigger neurogenesis and neuroprotection are particularly useful not only because of their therapeutic implications but also because they can provide an invaluable tool to study the mechanisms of neurogenesis. In this report, we have developed and screened 25 aminopropyl carbazole derivatives that can enhance neurogenesis of cultured neural stem cells. Among these analogues, compound 9 demonstrated an excellent proneurogenic and neuroprotective activity with no apparent toxicity. We believe that compound 9 can serve as an excellent lead to develop various analogues and to study the underlying mechanisms of neurogenesis. (C) 2013 Elsevier Ltd. All rights reserved.
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