A nanosystem for water-insoluble drugs prepared by a new technology, nanoparticulation using a solid lipid and supercritical fluid
- Authors
- Park, Joo Won; Yun, Jeong Min; Lee, Eun Seong; Youn, Yu Seok; Kim, Kab Sig; Oh, Young Taik; Oh, Kyung Teak
- Issue Date
- Nov-2013
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Insoluble drug; Nanoparticle; Supercritical fluid; Itraconazole; NUFS; Solid dispersion
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.36, no.11, pp 1369 - 1376
- Pages
- 8
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 36
- Number
- 11
- Start Page
- 1369
- End Page
- 1376
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14172
- DOI
- 10.1007/s12272-013-0187-2
- ISSN
- 0253-6269
1976-3786
- Abstract
- While the number and diversity of lead compounds has increased with the development of science technologies, ca. 90 % of new chemical entities under development have shown low aqueous solubility, classified as class II or IV of the biopharmaceutics classification system (BCS). The low aqueous solubility hinders their clinical translations due to low bioavailability and dissolution-limited absorption of orally-administered drugs. Several technologies have been employed to improve the solubility of poorly water-soluble drugs. In this paper, a new method of nanoparticulation using fat and a supercritical fluid (NUFS) for the formulation of hydrophobic drugs was applied to solve the low solubility problem. A typical BCS class II drug, itraconazole, was selected and formulated with hydroxypropyl methylcellulose, emulsification, and anticoagulating agents for NUFS. The non-spherical itraconazole nanoparticles prepared by NUFS were similar to 300-500 nm in size with a similar to 15-fold improved dissolution rate compared to non-nanoparticles of itraconazole (i.e., raw itraconazole). In addition, a high drug content of similar to 46 % by weight and a drug loading efficiency greater than 85 % were achieved. Therefore, the new technology for nano-platforms could be a promising solution for solubilization of poorly water-soluble drugs, resulting in improved bioavailability.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14172)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.