An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans
- Authors
- Kronstad, James W.; Hu, Guanggan; Jung, Won Hee
- Issue Date
- Sep-2013
- Publisher
- ELSEVIER SCI LTD
- Keywords
- heme; capsule; melanin; virulence; fungal pathogenesis; pH; cell wall; signaling
- Citation
- TRENDS IN MICROBIOLOGY, v.21, no.9, pp 457 - 465
- Pages
- 9
- Journal Title
- TRENDS IN MICROBIOLOGY
- Volume
- 21
- Number
- 9
- Start Page
- 457
- End Page
- 465
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14349
- DOI
- 10.1016/j.tim.2013.05.007
- ISSN
- 0966-842X
1878-4380
- Abstract
- Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that the pathogenic fungus Ctyptococcus neoformans overcomes iron limitation by multiple mechanisms that target transferrin and heme. The regulation of iron uptake is mediated by an interconnected set of transcription factors that include the master iron regulator Cir1 and the pH-responsive factor Rim101. These factors integrate iron homeostasis with a myriad of other functions including pH sensing, nutrient and stress signaling pathways, virulence factor elaboration, and cell wall biogenesis.
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- There are no files associated with this item.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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