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Whole genomic analysis reveals the co-evolutionary phylodynamics of Korean G9P[8] human rotavirus strains
- Authors
- Van Thai Than; Baek, In Hyuk; Kim, Wonyong
- Issue Date
- Aug-2013
- Publisher
- SPRINGER WIEN
- Keywords
- G9P[8]; Phylogenetic analysis; Rotavirus; NSP3
- Citation
- ARCHIVES OF VIROLOGY, v.158, no.8, pp 1795 - 1803
- Pages
- 9
- Journal Title
- ARCHIVES OF VIROLOGY
- Volume
- 158
- Number
- 8
- Start Page
- 1795
- End Page
- 1803
- ISSN
- 0304-8608
1432-8798
- Abstract
- Three human rotavirus G9P[8] strains, RVA/Human-tc/KOR/CAU05-202/2005/G9P[8], RVA/Human-tc/KOR/CAU09-371/2009/G9P[8], and RVA/Human-tc/KOR/CAU09-376/2009/G9P[8], were isolated from female pediatric patients with diarrhea from 2005 to 2009 using a cell culture system, and their complete genomic sequences were analyzed. The 11 gene segments of the three Korean strains possessed the G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1 genotype, which is closely related to the Wa-like genotype 1 constellation. Interestingly, the NSP2 and the NSP3 genes of strain RVA/Human-tc/KOR/CAU09-376/2009/G9P[8] were related to the G9 porcine or human-porcine reassortant strains, providing evidence for porcine-to-human interspecies transmission.
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