Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouseopen access
- Authors
- Hong, Seung Hwa; Sung, Rohyun; Kim, Young Chul; Suzuki, Hikaru; Choi, Woong; Park, Yeon Jin; Ji, Iii Woon; Kim, Chan Hyung; Myung, Sun Chul; Lee, Moo Yeol; Kang, Tong Mook; You, Ra Young; Lee, Kwang Ju; Lim, Seung Woon; Yun, Hyo-Yung; Song, Young-Jin; Xu, Wen-Xie; Kim, Hak Soon; Lee, Sang Jin
- Issue Date
- Aug-2013
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Relaxation; TASK-2; Uterus
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.4, pp 359 - 365
- Pages
- 7
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 17
- Number
- 4
- Start Page
- 359
- End Page
- 365
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14458
- DOI
- 10.4196/kjpp.2013.17.4.359
- ISSN
- 1226-4512
2093-3827
- Abstract
- Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K+ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch-activated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.
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