Effect of Lutein on L-NAME-Induced Hypertensive Rats
- Authors
- Sung, Ji Loon; Jo, Young Soo; Kim, Su Jin; Ryu, Jeong Soo; Kim, Myung Chul; Ko, Hyun Ju; Sim, Sang Soo
- Issue Date
- Aug-2013
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Antioxidant; Hypertension; Lipid peroxidation; L-NAME; Lutein
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.4, pp 339 - 345
- Pages
- 7
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 17
- Number
- 4
- Start Page
- 339
- End Page
- 345
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14459
- DOI
- 10.4196/kjpp.2013.17.4.339
- ISSN
- 1226-4512
2093-3827
- Abstract
- We investigated the antihypertensive effect of lutein on N-G-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3 +/- 9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 43426 to 376 33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation. four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against LNAME-induced hypertension in rats.
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