Decreasing Effect of Lidocaine center dot HCl on the Thickness of the Neuronal and Model Membrane
- Authors
- Park, Sung-Min; Park, Jong-Sun; Kim, Jae-Han; Baek, Jin-Hyun; Yoon, Tae-Gyun; Lee, Do-Keun; Ryu, Won-Hyang; Chung, In-Kyo; Sohn, Uy Dong; Jang, Hye-Ock; Yun, Il
- Issue Date
- Aug-2013
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Fluorescence quenching technique; Lidocaine center dot HCl; Membrane thickness; Model membranes; Neuronal membranes
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.4, pp 253 - 257
- Pages
- 5
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 17
- Number
- 4
- Start Page
- 253
- End Page
- 257
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14460
- DOI
- 10.4196/kjpp.2013.17.4.253
- ISSN
- 1226-4512
2093-3827
- Abstract
- This study examined the mechanism of action of a local anesthetic, lidocaine center dot HCl. Energy transfer between the surface fluorescent probe, 1-anilinonaphthalene-8-sulfonic acid, and the hydrophobic fluorescent probe, 1,3-di(1-pyrenyl) propane, was used to determine the effect of lidocaine center dot HCl on the thickness (D) of the synaptosomal plasma membrane vesicles (SPMV) isolated from the bovine cerebral cortex, and liposomes of the total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. The thickness (D) of the intact SPMV, SPMVTL and SPMVPL were 1.044 +/- 0.008, 0.914 +/- 0.005 and 0.8900 +/- 003 (arbitrary units, n=5) at 37 degrees C (pH 7.4), respectively. Lidocaine center dot HCl decreased the thickness of the neuronal and model membrane lipid bilayers in a dose-dependent manner with a significant decrease in the thickness, even at 0.1 mM. The decreasing effect of lidocaine center dot HCl on the membrane thickness might be responsible for some, but not all of its anesthetic action.
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