Direct observation of CD4 T cell morphologies and their cross-sectional traction force derivation on quartz nanopillar substrates using focused ion beam technique
- Authors
- Kim, Dong-Joo; Kim, Gil-Sung; Hyung, Jung-Hwan; Lee, Won-Yong; Hong, Chang-Hee; Lee, Sang-Kwon
- Issue Date
- Jul-2013
- Publisher
- SPRINGER
- Keywords
- Cell traction force; Cell adhesion; CD4 T cell; Cell migration; Focused ion beam
- Citation
- NANOSCALE RESEARCH LETTERS, v.8, no.1
- Journal Title
- NANOSCALE RESEARCH LETTERS
- Volume
- 8
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14463
- DOI
- 10.1186/1556-276X-8-332
- ISSN
- 1556-276X
1556-276X
- Abstract
- Direct observations of the primary mouse CD4 T cell morphologies, e.g., cell adhesion and cell spreading by culturing CD4 T cells in a short period of incubation (e.g., 20 min) on streptavidin-functionalized quartz nanopillar arrays (QNPA) using a high-content scanning electron microscopy method were reported. Furthermore, we first demonstrated cross-sectional cell traction force distribution of surface-bound CD4 T cells on QNPA substrates by culturing the cells on top of the QNPA and further analysis in deflection of underlying QNPA via focused ion beam-assisted technique.
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Collections - College of Natural Sciences > Department of Physics > 1. Journal Articles
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