Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring
- Authors
- Lee, Sangmi; Lee, Kyung A.; Choi, Gyu Yeon; Desai, Mina; Lee, Sun Hwa; Pang, Myung-Geol; Jo, Inho; Kim, Young Ju
- Issue Date
- Jun-2013
- Publisher
- INFORMA HEALTHCARE
- Keywords
- Adiponectin; fetal programming; food restriction; leptin; obesity
- Citation
- JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, v.26, no.9, pp 908 - 914
- Pages
- 7
- Journal Title
- JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
- Volume
- 26
- Number
- 9
- Start Page
- 908
- End Page
- 914
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14576
- DOI
- 10.3109/14767058.2013.766686
- ISSN
- 1476-7058
1476-4954
- Abstract
- Objective: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. Study design: From 10 d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. Results: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p < 0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p < 0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. Conclusion: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
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