Randomized trial comparing the efficacy between different types of paclitaxel-eluting stents: The comparison of Efficacy between COroflex PLEASe ANd Taxus stent (ECO-PLEASANT) randomized controlled trial
- Authors
- Seo, Jae-Bin; Kang, Si-Hyuck; Hur, Seung-Ho; Park, Kyung Woo; Youn, Tae-Jin; Park, Jong-Seon; Yang, Han-Mo; Lee, Hae-Young; Kang, Hyun-Jae; Koo, Bon-Kwon; Bae, Jang-Ho; Kim, Sang-Wook; Moon, Keon-Woong; Choi, Jae-Woong; Lee, Sang-Gon; Chung, Woo-Young; Kim, Soo-Joong; Kim, Doo-Il; Kim, Byung-Ok; Hyon, Min-Su; Park, Keum-Soo; Cha, Tae-Joon; Yoo, Chul-Woong; Jeon, Hui-Kyung; Kim, Hyo-Soo
- Issue Date
- May-2013
- Publisher
- MOSBY-ELSEVIER
- Citation
- AMERICAN HEART JOURNAL, v.165, no.5, pp 733 - 743
- Pages
- 11
- Journal Title
- AMERICAN HEART JOURNAL
- Volume
- 165
- Number
- 5
- Start Page
- 733
- End Page
- 743
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14677
- DOI
- 10.1016/j.ahj.2013.02.009
- ISSN
- 0002-8703
1097-5330
- Abstract
- Aims Paclitaxel-eluting stents (PESs) have been shown to inhibit neointimal hyperplasia after percutaneous coronary intervention. Coroflex Please (B Braun, Melsungen, Germany) is a newly developed PES. We compared the clinical and angiographic efficacy of Coroflex Please with Taxus Liberte (Boston Scientific, Natick, MA) in a real-world practice. Methods and Results We performed a prospective, open-label, randomized, controlled study that enrolled 945 patients undergoing percutaneous coronary interventions in 18 centers in Korea. The primary end point was clinically driven target vessel revascularization at 9 months. The baseline characteristics were mostly similar and comparable between 2 groups. At 9 months, the incidence of clinically driven target vessel revascularization was 14.6% for Coroflex and 6.4% for Taxus, which was significantly different (hazard ratio 2.43, 95% CI 1.50-3.94, noninferiority P value = 1.000). This is well corroborated by the difference of in-stent late loss between 2 stents (0.71 +/- 0.64 mm vs 0.52 +/- 0.50 mm, P < .001) by 9-month follow-up angiography (n = 415 vs 215). Among secondary clinical end points, stent thrombosis (definite and probable) for 1 year was 2.2% in Coroflex and 1.3% in Taxus (P = .317). Also, myocardial infarction for 9 months was higher in Coroflex group than that in Taxus (4.9% vs 1.6%, P = .012), which was partly contributed by the higher incidence of periprocedural myocardial infarction in Coroflex arm (2.2% vs 0.3%, P = .028). Conclusions Coroflex Please was inferior to Taxus Liberte with regard to clinical and angiographic efficacy. (Am Heart J 2013;165:733-43.)
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