The value of preoperative PET-CT in papillary thyroid cancer
- Authors
- Kim, Byung Seup; Ryu, Han Suk; Kang, Kyung Ho
- Issue Date
- Apr-2013
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Papillary thyroid cancer; positron emission tomography-computed tomography (PET-CT)
- Citation
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.41, no.2, pp 445 - 456
- Pages
- 12
- Journal Title
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Volume
- 41
- Number
- 2
- Start Page
- 445
- End Page
- 456
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14755
- DOI
- 10.1177/0300060513475743
- ISSN
- 0300-0605
1473-2300
- Abstract
- Objective: To evaluate the clinical usefulness of preoperative positron emission tomography-computed tomography (PET-CT) in primary papillary thyroid cancer (PTC). Methods: Preoperative PET-CT scans of patients with biopsy-confirmed PTC who were undergoing thyroidectomy were examined and the maximum standardized uptake value (SUVmax) of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18-FDG) was calculated. Demographic and clinical data were obtained from medical records. Tumour tissue was pathologically classified according to World Health Organization guidelines. Univariate and multivariate analyses were performed to determined the demographic, clinical and pathological factors affecting PET positivity and SUVmax. Results: The study included 194 patients. Multivariate analysis indicated that patients were significantly more likely to be PET positive if they were female, had larger tumours (>1 cm), coexisting pathology (nodular hyperplasia or Hashimoto's thyroiditis) or nonfollicular variant PTC. SUVmax <2.0 indicated possible follicular variant PTC. Conclusions: PET-positive results were unrelated to extrathyroidal extension and lymph node metastasis. PET positivity was related to larger tumour size and implied coexisting pathology. PET negativity or low SUVmax suggested possible follicular variant PTC.
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