Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Soung Baek | - |
dc.contributor.author | Kim, Dongju | - |
dc.contributor.author | Kim, Seong Yeon | - |
dc.contributor.author | Park, Changhee | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Kuh, Hyo-Jeong | - |
dc.contributor.author | Lee, Jaehwi | - |
dc.date.available | 2019-03-09T02:03:46Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14865 | - |
dc.description.abstract | The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2013.17.1.9 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.1, pp 9 - 13 | - |
dc.identifier.kciid | ART001746096 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000334564500002 | - |
dc.identifier.scopusid | 2-s2.0-84876754894 | - |
dc.citation.endPage | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Beta-lapachone | - |
dc.subject.keywordAuthor | Mixed micelles | - |
dc.subject.keywordAuthor | Permeability | - |
dc.subject.keywordAuthor | Single-pass intestinal perfusion | - |
dc.subject.keywordPlus | WATER-SOLUBLE DRUG | - |
dc.subject.keywordPlus | ENHANCED ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | UNSTIRRED LAYER | - |
dc.subject.keywordPlus | MIXED MICELLES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | PERFUSION | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.