Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
- Authors
- Jang, Soung Baek; Kim, Dongju; Kim, Seong Yeon; Park, Changhee; Jeong, Ji Hoon; Kuh, Hyo-Jeong; Lee, Jaehwi
- Issue Date
- Feb-2013
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Beta-lapachone; Mixed micelles; Permeability; Single-pass intestinal perfusion
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.1, pp 9 - 13
- Pages
- 5
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 17
- Number
- 1
- Start Page
- 9
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14865
- DOI
- 10.4196/kjpp.2013.17.1.9
- ISSN
- 1226-4512
2093-3827
- Abstract
- The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
- College of Medicine > College of Medicine > 1. Journal Articles
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