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Poly(L-aspartic acid) nanogels for lysosome-selective antitumor drug delivery

Authors
Oh, Nam MukOh, Kyung TaekYoun, Yu SeokLee, Deok-KeunCha, Kyung-HoiLee, Don HaengLee, Eun Seong
Issue Date
Jan-2013
Publisher
ELSEVIER SCIENCE BV
Keywords
Poly(L-aspartic acid) derivative nanogels; 3-Diethylaminopropyl; pH-sensitive nanogels; Lysosomal pH; Tumor therapy
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v.101, pp 298 - 306
Pages
9
Journal Title
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume
101
Start Page
298
End Page
306
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14954
DOI
10.1016/j.colsurfb.2012.07.013
ISSN
0927-7765
1873-4367
Abstract
Advanced materials that have controllable pH-responsive properties when submerged in the lysosome have a great potential in intracellular drug delivery. We developed novel poly(L-amino acid) nanogels that were prepared by a facile cross-linking of poly[L-aspartic acid-g-(3-diethylaminopropyl)]-b-poly(ethylene glycol)-maleimide [poly(L-Asp-g-DEAP)-b-PEG-Mal] and poly(L-aspartic acid-g-ethyl thiol)-b-PEG [poly(L-Asp-SH)-b-PEG] in an oil/water emulsion condition. Interestingly, these nanogels (similar to 125 nm in diameter) modulated volume expansion (similar to 375 nm in diameter) in a lysosomal pH (similar to pH 5.0) due to an extensive proton absorption of DEAP at a low pH, which mediated lysosome swelling and the subsequent lysosome destabilization. In the in vitro tumor cell cytotoxicity test, they encouraged tumor cell death, probably owing to the leakage of lysosomal enzymes. Furthermore, encapsulating antitumor drug (e.g., doxorubicin, DOX) into these nanogels enhanced tumor cell cytotoxicity. We conclude that this nanogel system will have great potential for tumor therapy. (C) 2012 Elsevier B.V. All rights reserved.
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Oh, Kyung Taek
대학원 (글로벌혁신신약학과)
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