Enhanced dissolution of celecoxib by supersaturating self-emulsifying drug delivery system (S-SEDDS) formulation
- Authors
- Song, Woo Heon; Park, Jong Hyeok; Yeom, Dong Woo; Ahn, Byeong Kil; Lee, Kyung Min; Lee, Sang Gon; Woo, Hye Seung; Choi, Young Wook
- Issue Date
- Jan-2013
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Celecoxib; Self-emulsification; S-SEDDS; Soluplus; Solubilization; Supersaturation
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.36, no.1, pp 69 - 78
- Pages
- 10
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 36
- Number
- 1
- Start Page
- 69
- End Page
- 78
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15006
- DOI
- 10.1007/s12272-013-0011-z
- ISSN
- 0253-6269
1976-3786
- Abstract
- A supersaturating self-emulsifying drug delivery system (S-SEDDS) was prepared and evaluated for enhanced dissolution of celecoxib (CXB), a poorly water-soluble drug. The selected CXB-dissolved SEDDS formulation consisting 10 % Capryol 90 (oil), 45 % Tween 20 (surfactant), and 45 % Tetraglycol (cosurfactant) had the characteristics of small droplet size and great solubility as 208 nm and 556.7 mg/mL in average, respectively. CXB dissolution from SEDDS in simulated gastric fluid was increased to about 20 % for the initial period of 5 min, but decreased to a half level as time elapsed. Thus, precipitation inhibitors were screened to stabilize the supersaturation. The stabilizing effect of Soluplus, an amphiphilic copolymer, was concentration-dependent, revealing the greatest dissolution of approximately 90 % level with delayed drug crystallization by the addition of the copolymer. CXB dissolution from S-SEDDS was pH-independent. We concluded that S-SEDDS formulation would be very useful in the future for developing oral delivery product of poorly water-soluble drugs.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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