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Liposomal doxorubicin-loaded chitosan microspheres capable of controlling release of doxorubicin for anti-cancer chemoembolization: in vitro characteristics
- Issue Date
- 2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Liposomal doxorubicin; Chemoembolization; Chitosan; Release
- Citation
- JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v.23, no.3, pp 283 - 286
- Pages
- 4
- Journal Title
- JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Volume
- 23
- Number
- 3
- Start Page
- 283
- End Page
- 286
- ISSN
- 1773-2247
- Abstract
- The aim of this study was to develop liposomal doxorubicin-loaded chitosan microspheres (LDox-CSMS) for anti-cancer chemoembolization. LDox-CSMS and doxorubicin-loaded CSMS (Dox-CSMS) devoid of liposomal carrier were prepared with an emulsification and cross-linking method. Various stirring rates were required to obtain large fractions of CSMS in the size range of 300-500 mu m. Drug loading amounts were considerably influenced by the amount of doxorubicin-loaded liposomes added. Drug release from LDox-CSMS was controlled by the drug loading amount, which was varied by the addition of liposomal doxorubicin. These results indicate that LDox-CSMS can be used as an advanced chemoembolic agent that can control drug release behaviors.
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