Poly(L-aspartic acid) derivative soluble in a volatile organic solvent for biomedical application
- Authors
- Oh, Nam Muk; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong
- Issue Date
- Sep-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Poly(L-aspartic acid) derivative; Diethylaminopropyl group; Volatile solvent; pH-sensitive polymer
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.97, pp 190 - 195
- Pages
- 6
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 97
- Start Page
- 190
- End Page
- 195
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15132
- DOI
- 10.1016/j.colsurfb.2012.03.024
- ISSN
- 0927-7765
1873-4367
- Abstract
- In order to develop a novel functional poly(L-amino acid) that can dissolve in volatile organic solvents, we prepared poly[L-aspartic acid-g-(3-diethylaminopropyl)]-b-poly(ethylene glycol) [poly(L-Asp-g-DEAP)-b-PEG] via the conjugation of 3-diethylaminopropyl (DEAP) to carboxylate groups of poly(L-Asp) (M-n 4 K)-b-PEG (M-n 2 K). This poly(L-aspartic acid) derivative evidenced a relatively high solubility in volatile organic solvents such as dichloromethane. chloroform, and acetone. We fabricated a model nanostructure (i.e., polymeric micelle) using poly(L-Asp-g-DEAP)-b-PEG by the film rehydration method, which involves the simple removal of the volatile organic solvent (dichloromethane) used to dissolve polymer, reducing concerns about organic solvents remaining in a nano-sized particle. Interestingly, this micelle showed the pH-stimulated release of encapsulated model drug [i.e., doxorubicin (DOX)] due to the protonation of DEAP according to the pH of the solution. We expect that this poly(L-aspartic acid) derivative promises to provide pharmaceutical potential for constituting a new stimuli-sensitive drug carrier for various drug molecules. (c) 2012 Elsevier B.V. All rights reserved.
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