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Development of a Plastic-Based Microfluidic Immunosensor Chip for Detection of H1N1 Influenzaopen access
- Authors
- Lee, Kyoung G.; Lee, Tae Jae; Jeong, Soon Woo; Choi, Ho Woon; Heo, Nam Su; Park, Jung Youn; Park, Tae Jung; Lee, Seok Jae
- Issue Date
- Aug-2012
- Publisher
- MDPI AG
- Keywords
- immunosensor; H1N1 influenza; microfluidics; plastic chip
- Citation
- SENSORS, v.12, no.8, pp 10810 - 10819
- Pages
- 10
- Journal Title
- SENSORS
- Volume
- 12
- Number
- 8
- Start Page
- 10810
- End Page
- 10819
- ISSN
- 1424-8220
1424-8220
- Abstract
- Lab-on-a-chip can provide convenient and accurate diagnosis tools. In this paper, a plastic-based microfluidic immunosensor chip for the diagnosis of swine flu (H1N1) was developed by immobilizing hemagglutinin antigen on a gold surface using a genetically engineered polypeptide. A fluorescent dye-labeled antibody (Ab) was used for quantifying the concentration of Ab in the immunosensor chip using a fluorescent technique. For increasing the detection efficiency and reducing the errors, three chambers and three microchannels were designed in one microfluidic chip. This protocol could be applied to the diagnosis of other infectious diseases in a microfluidic device.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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