IL-1 beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H pylori eradication in gastroduodenal phenotypes
- Authors
- Chang, Young Woon; Oh, Hyoung-Chul; Jang, Jae Young; Hwangbo, Young; Lee, Jae Won; Lee, Hyo Jung; Joo, Kwang Ro; Dong, Seok Ho; Kim, Sung Soo; Kim, Hyo Jong; Kim, Byung Ho; Chang, Rin
- Issue Date
- 2008
- Publisher
- INFORMA HEALTHCARE
- Keywords
- gastroduodenal phenotypes; Helicobacter pylori; IL-1B genotypes
- Citation
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.43, no.10, pp 1184 - 1193
- Pages
- 10
- Journal Title
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Volume
- 43
- Number
- 10
- Start Page
- 1184
- End Page
- 1193
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15261
- DOI
- 10.1080/00365520802130209
- ISSN
- 0036-5521
1502-7708
- Abstract
- Objective. Relations between host genetic factors and clinical outcomes of Helicobacter pylori infection are variable among ethnicities. The aim of this study was to examine gastric mucosal cytokines, matrix metalloproteinase 3 (MMP-3), and serum pepsinogen levels before and after eradication of H. pylori according to IL-1B genotypes and benign gastroduodenal phenotypes in a Korean population. Material and methods. A total of 349 Koreans including H. pylori-infected subjects (n=230) and H. pylori-negative controls (n=119) were enrolled. The former subjects were classified into groups according to the presence of non-atrophic gastritis (n=74), atrophic gastritis (n=56), gastric ulcer (n=37), and duodenal ulcer (n=63). IL-1B polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Gastric mucosal IL-1 beta, IL-8, and MMP-3, and serum pepsinogen I and II levels were measured by ELISA and radioimmunoassay, respectively. Results. There were no significant differences between the IL-1B-31/-511 haplotype (TT/CC, CT/CT, and CC/TT) frequencies among the H. pylori-positive and -negative groups. The genotypes of IL-1B-31/-511 polymorphisms did not affect clinical phenotypes, inflammatory cytokines, MMP-3, and pepsinogen secretion. Subjects with H. pylori-infected atrophic gastritis exhibited significantly higher basal levels of cytokines and a lower pepsinogen I/II ratio than those of other groups. Following H. pylori eradication, inflammatory cytokines significantly decreased and the pepsinogen I/II ratio increased in all groups. Conclusions. Mucosal inflammatory cytokines, MMP-3, and pepsinogen secretion are related to gastroduodenal phenotypes but not to IL-1B genotypes. Eradication of H. pylori can reduce mucosal inflammation and restore pepsinogen secretion.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15261)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.