Acute hepatitis A-associated acute renal failure in adults
- Authors
- Kim, Su Hyun; Yoon, Hye Eun; Kim, Yong Kyun; Kim, Jin Young; Choi, Bum Soon; Choi, Young Jin; Kim, Young Ok; Kim, Yong Soo; Bang, Byung Kee; Yang, Chul Woo
- Issue Date
- Aug-2008
- Publisher
- KARGER
- Keywords
- acute renal failure; acute hepatitis A; dialysis
- Citation
- NEPHRON CLINICAL PRACTICE, v.109, no.3, pp C127 - C132
- Journal Title
- NEPHRON CLINICAL PRACTICE
- Volume
- 109
- Number
- 3
- Start Page
- C127
- End Page
- C132
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15265
- DOI
- 10.1159/000145455
- ISSN
- 1660-2110
1423-0186
- Abstract
- Background/Aims: The development of acute renal failure (ARF) is a very rare complication in patients with acute hepatitis A (AHA). Methods: We retrospectively investigated the overall incidence, risk factors, and clinical outcomes of ARF associated with AHA. Diagnosis of AHA was made according to the typical hepatitis symptoms and positivity of immunoglobulin M anti-hepatitis A virus in 208 patients with AHA. Results: ARF was noted in 12 (5.7%) patients, and dialysis was required in 8 (66%) patients. The median duration of hospitalization for patients with ARF was 18 days (range, 6-50 days). The development of ARF was observed in older patients (p = 0.004) and in patients with diabetes (p = 0.001), excessive alcohol consumption (p = 0.01), prolonged international normalized ratio (p = 0.019), and elevated aspartate aminotransferase concentration (p = 0.034). Multivariate analysis revealed that old age (odds ratio, OR, 1.2), elevated aspartate aminotransferase concentration (OR, 1.05), and diabetes (OR, 18.5) were independent risk factors for ARF ( each p < 0.001). The prognosis of patients with ARF was good, and renal function recovered completely. Conclusion: ARF associated with AHA is not rare, and the possibility of AHA should be considered in patients with ARF with hepatic dysfunction. Copyright (c) 2008 S. Karger AG, Basel.
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