Impact of gut microbiota on drug metabolism: an update for safe and effective use of drugs
- Authors
- Noh, Keumhan; Kang, You Ra; Nepal, Mahesh Raj; Shakya, Rajina; Kang, Mi Jeong; Kang, Wonku; Lee, Sangkyu; Jeong, Hye Gwang; Jeong, Tae Cheon
- Issue Date
- Dec-2017
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Gut microbiota; Drug metabolism; Pharmacokinetics; Pharmacodynamics; Toxicity
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.40, no.12, pp 1345 - 1355
- Pages
- 11
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 40
- Number
- 12
- Start Page
- 1345
- End Page
- 1355
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1587
- DOI
- 10.1007/s12272-017-0986-y
- ISSN
- 0253-6269
1976-3786
- Abstract
- The intestinal mucosa and liver have long been considered as the main sites of drug metabolism, and the contribution of gut microbiota to drug metabolism has been under-estimated. However, it is now generally accepted that the gut microbiota plays an important role in drug metabolism prior to drug absorption or during enterohepatic circulation via various microbial enzymatic reactions in the intestine. Moreover, some drugs are metabolized by gut microbiota to specific metabolite(s) that cannot be formed in the liver. More importantly, the metabolism of drugs by gut microbiota prior to absorption can alter the systemic bioavailability of certain drugs. Therefore, understanding drug metabolism by gut microbiota is critical for explaining changes in the pharmacokinetics of drugs, which may cause significant alterations in drug-induced pharmacodynamics and toxicities. In this review, we describe recent progress with regard to the role of metabolism by gut microbiota in some drug-induced alterations of either pharmacological or toxicological effects to emphasize the clinical importance of gut microbiota for safe and effective use of drugs.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1587)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.