Crosslinking method of hyaluronic-based hydrogel for biomedical applicationsopen access
- Authors
- Khunmanee, Sureerat; Jeong, Younghyen; Park, Hansoo
- Issue Date
- Sep-2017
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- Hyaluronic acid; crosslinking method; tissue engineering
- Citation
- JOURNAL OF TISSUE ENGINEERING, v.8
- Journal Title
- JOURNAL OF TISSUE ENGINEERING
- Volume
- 8
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1595
- DOI
- 10.1177/2041731417726464
- ISSN
- 2041-7314
- Abstract
- In the field of tissue engineering, there is a need for advancement beyond conventional scaffolds and preformed hydrogels. Injectable hydrogels have gained wider admiration among researchers as they can be used in minimally invasive surgical procedures. Injectable gels completely fill the defect area and have good permeability and hence are promising biomaterials. The technique can be effectively applied to deliver a wide range of bioactive agents, such as drugs, proteins, growth factors, and even living cells. Hyaluronic acid is a promising candidate for the tissue engineering field because of its unique physicochemical and biological properties. Thus, this review provides an overview of various methods of chemical and physical crosslinking using different linkers that have been investigated to develop the mechanical properties, biodegradation, and biocompatibility of hyaluronic acid as an injectable hydrogel in cell scaffolds, drug delivery systems, and wound healing applications.
- Files in This Item
-
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1595)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.