High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats
- Authors
- Hai-Quyen Tran; Chung, Yoon Hee; Shin, Eun-Joo; Kim, Won Ki; Lee, Jae-Chul; Jeong, Ji Hoon; Wie, Myung Bok; Jang, Choon-Gon; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung-Chun
- Issue Date
- Oct-2016
- Publisher
- JAPANESE PHARMACOLOGICAL SOC
- Keywords
- High-dose dextromethorphan; Administration route; Myelinoid bodies with mitochondrial dysfunction
- Citation
- JOURNAL OF PHARMACOLOGICAL SCIENCES, v.132, no.2, pp 166 - 170
- Pages
- 5
- Journal Title
- JOURNAL OF PHARMACOLOGICAL SCIENCES
- Volume
- 132
- Number
- 2
- Start Page
- 166
- End Page
- 170
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1777
- DOI
- 10.1016/j.jphs.2016.10.001
- ISSN
- 1347-8613
1347-8648
- Abstract
- Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses. Treatment with DM resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated DM-induced cytosolic oxidative burdens. However, neither MK-801 nor naloxone affected DM-induced mitochondrial dysfunction and formation of myelinoid bodies, indicating that the neurotoxic mechanism needs to be further elucidated. Therefore, the spectrum of toxicological effects associated with DM need to be reassessed. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
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